l-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase
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چکیده
منابع مشابه
Bacterial Threonine Aldolase and Serine Hydroxymethyltransferase Enzymes
for the enzyme in vivo unless an alkaline micro-environment was postulated or conditions were present in vivo which could potentiate inhibition by UMP at near-neutral pH (Yon, 19726). Substances such as deoxycholate which can bind to the hydrophobic site on the enzyme may provide such potentiation. Fig. 2 shows the effects of UMP and deoxycholate at pH values between 7 and 11. In the absence of...
متن کاملEnzymatic Breakdown of Threonine by Threonine Aldolase
1. The enzyme which splits threonine to acetaldehyde and glycine has been partially purified from rat liver (five- to sixfold purification) and the name threonine aldolase proposed for it. 2. The general properties of threonine aldolase have been studied. The enzyme is unstable to a pH below 5. The pH optimum of the enzyme reaction is at 7.5-7.7. The initial rate of production of acetaldehyde i...
متن کاملSerine hydroxymethyltransferase from Solanum tuberosum.
SHMT, EC 2.1.2.1, catalyzes the interconversion of Ser and Gly accompanied by the production or consumption of one-carbon units. In leaves it is a component of the photorespiratory pathway (Keys et al., 1978). The main function of that pathway is the salvage of reduced carbon and nitrogen withdrawn from the Calvin cycle by the oxygenation of ribulose 1,5-bisphosphate. By the cooFeration of SHMT...
متن کاملCharacterization of serine hydroxymethyltransferase GlyA as a potential source of D-alanine in Chlamydia pneumoniae
For intracellular Chlamydiaceae, there is no need to withstand osmotic challenges, and a functional cell wall has not been detected in these pathogens so far. Nevertheless, penicillin inhibits cell division in Chlamydiaceae resulting in enlarged aberrant bodies, a phenomenon known as chlamydial anomaly. D-alanine is a unique and essential component in the biosynthesis of bacterial cell walls. I...
متن کاملEffect of Alanine and Threonine on the Synthesis of Serine by Leuconostoc Mesenteroides.
O'Barr, Thomas P. (Agricultural Research Service, Washington, D.C.). Effect of alanine and threonine on the synthesis of serine by Leuconostoc mesenteroides. J. Bacteriol. 86:1321-1325. 1963.-Growth of Leuconostoc mesenteroides in the absence of serine was inhibited by l-alanine and l-threonine. Varying the glycine concentration when l-alanine was present suggested a direct relationship between...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 2001
ISSN: 0014-2956
DOI: 10.1046/j.0014-2956.2001.02606.x